Structure of PDB 5fbo Chain A

Receptor sequence
>5fboA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDE
FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRH
RFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFG
LSSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNS
ETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDV
MDEES
3D structure
PDB5fbo Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
ChainA
Resolution1.894 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D521 A523 R525 N526 D539 F559
Catalytic site (residue number reindexed from 1) D130 A132 R134 N135 D148 F155
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5WH A L408 V416 A428 K430 E445 M449 I472 T474 M477 G480 C481 N484 L528 D539 L542 L17 V25 A37 K39 E54 M58 I81 T83 M86 G89 C90 N93 L137 D148 L151 MOAD: ic50=0.31nM
PDBbind-CN: -logKd/Ki=9.51,IC50=0.31nM
BindingDB: IC50=0.300000nM
BS02 5WE A S394 W395 I397 W421 Y425 S453 Y461 S3 W4 I6 W30 Y34 S62 Y70
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5fbo, PDBe:5fbo, PDBj:5fbo
PDBsum5fbo
PubMed26985298
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

[Back to BioLiP]