Structure of PDB 5fbk Chain A

Receptor sequence
>5fbkA (length=487) Species: 9606 (Homo sapiens) [Search protein sequence]
PDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWL
QAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKID
SLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSS
RLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRP
GIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFS
SGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFA
LKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENIS
SVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADI
KKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGS
IVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPF
3D structure
PDB5fbk Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TCR A R66 W70 G146 S147 A168 S169 S170 Y218 E297 A298 R45 W49 G125 S126 A147 S148 S149 Y197 E276 A277
BS02 BCT A R66 R69 W70 L414 R415 I416 S417 R45 R48 W49 L362 R363 I364 S365
BS03 MG A I81 L87 L88 I60 L66 L67
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fbk, PDBe:5fbk, PDBj:5fbk
PDBsum5fbk
PubMed27386547
UniProtP41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)

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