Structure of PDB 5f9l Chain A

Receptor sequence

>5f9lA (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMR
AAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMP
IRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAM
CRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEER
LTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFT
VIKNCNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

5f9l Bypass of the 1, N2-Ethenodeoxyguanosine Lesion by Human DNA Polymerase Eta

Chain

Resolution

2.592 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	W42 R61 S62 K86 R313 P316 K317 T318 G320 S322 K323 N324 P326	W45 R64 S65 K89 R312 P315 K316 T317 G319 S321 K322 N323 P325
BS02	dna	A	S113 E116 K224 S257 G259 G260 K261 L262 L381 R382 R383	S116 E119 K223 S256 G258 G259 K260 L261 L380 R381 R382
BS03	DZ4	A	D13 M14 C16 F17 F18 I48 Y52 R55 R61 D115 K231	D16 M17 C19 F20 F21 I51 Y55 R58 R64 D118 K230
BS04	MG	A	D13 M14 D115	D16 M17 D118
BS05	MG	A	D13 D115 E116	D16 D118 E119

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5f9l, PDBe:5f9l, PDBj:5f9l
PDBsum	5f9l
PubMed
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

[Back to BioLiP]