Structure of PDB 5f8t Chain A

Receptor sequence
>5f8tA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLP
LQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQ
APLNYTEFQKPISLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMW
RLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSD
3D structure
PDB5f8t The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H44 D93 K185 G186 D187 S188 G189
Enzyme Commision number 3.4.21.34: plasma kallikrein.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R39 H57 D60 V96 E98 Y174 K192 G193 S195 S214 W215 G216 E217 R26 H44 D47 V87 E89 Y165 K185 G186 S188 S207 W208 G209 E210
BS02 MRZ A D189 A190 T213 W215 G219 D182 A183 T206 W208 G211
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5f8t, PDBe:5f8t, PDBj:5f8t
PDBsum5f8t
PubMed
UniProtP03952|KLKB1_HUMAN Plasma kallikrein (Gene Name=KLKB1)

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