Structure of PDB 5f84 Chain A

Receptor sequence
>5f84A (length=365) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
NEDEFSFKIRRQIEKANADYKPCSSDPQDSDCSCHANVLKRDLAPYKSTG
VTRQMIESSARYGTKYKIYGHRLYRDANCMFPARCEGIEHFLLPLVATLP
DMDLIINTRDYPQLNAAWGNAAGGPVFSFSKTKEYRDIMYPAWTFWAGGP
ATKLHPRGIGRWDQMREKLEKRAAAIPWSQKRSLGFFRGSRTSDERDSLI
LLSRRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFEDHCKYKYLFNFR
GVAASFRLKHLFLCKSLVFHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQE
YEHILSFFKKNDALAQEIAQRGYDFIWEHLRMKDIKCYWRKLLKRYVKLL
QYEVKPEDQLIYIGP
3D structure
PDB5f84 Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A I200 R229 S231 T233 R237 E275 V276 F278 S296 R298 I159 R188 S190 T192 R196 E234 V235 F237 S255 R257
BS02 BGC A D151 V293 A294 A295 F297 D110 V252 A253 A254 F256
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0035251 UDP-glucosyltransferase activity
GO:0035252 UDP-xylosyltransferase activity
GO:0046527 glucosyltransferase activity
GO:0140561 EGF-domain serine glucosyltransferase activity
GO:0140562 EGF-domain serine xylosyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0007219 Notch signaling pathway
GO:0018242 protein O-linked glycosylation via serine
GO:0042052 rhabdomere development
GO:0045165 cell fate commitment
GO:0045746 negative regulation of Notch signaling pathway
GO:0045747 positive regulation of Notch signaling pathway
GO:0060537 muscle tissue development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0012505 endomembrane system

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5f84, PDBe:5f84, PDBj:5f84
PDBsum5f84
PubMed27428513
UniProtQ8T045|RUMI_DROME O-glucosyltransferase rumi (Gene Name=rumi)

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