Structure of PDB 5f6c Chain A

Receptor sequence
>5f6cA (length=512) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
RHMKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYKGKITR
IEPSLEAAFVDYGAERHGFLPLKEIAREYFPANYSAHGRPNIKDVLREGQ
EVIVQIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIEGDDR
TELKEALASLELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAA
ESRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALG
RPDFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEA
LTAIRINSARATRGGDIEETAFNTNLEAADEIARQLRLRDLGGLIVIRFI
DMTPVRHQRAVENRLREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGE
SSHHVCPRCSGTGTVRDNESLSLSILRLIEEEALKENTQEVHAIVPVPIA
SYLLNEKRSAVNAIETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTL
SYMLPKLHEEAM
3D structure
PDB5f6c Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E.
ChainA
Resolution3.002 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A V128 A136 I139 S140 R141 I167 R169 T170 R373 V130 A138 I141 S142 R143 I169 R171 T172 R375
BS02 MG A D26 L27 D28 R335 D338 D28 L29 D30 R337 D340
BS03 ZN A C404 C407 C406 C409
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5f6c, PDBe:5f6c, PDBj:5f6c
PDBsum5f6c
PubMed30270108
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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