Structure of PDB 5f60 Chain A

Receptor sequence
>5f60A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5f60 Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5VZ A W81 P82 F83 V87 L92 L94 N140 I146 W40 P41 F42 V46 L51 L53 N99 I105 MOAD: Kd=43nM
PDBbind-CN: -logKd/Ki=7.37,Kd=43nM
External links
PDB RCSB:5f60, PDBe:5f60, PDBj:5f60
PDBsum5f60
PubMed28336808
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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