Structure of PDB 5f5b Chain A

Receptor sequence
>5f5bA (length=182) Species: 562 (Escherichia coli) [Search protein sequence]
ERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFT
HALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQ
KFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNA
3D structure
PDB5f5b Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.105: rhomboid protease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M120 F146 H150 W196 F197 G198 G199 S201 S248 M249 A250 M30 F56 H60 W106 F107 G108 G109 S111 S158 M159 A160
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5f5b, PDBe:5f5b, PDBj:5f5b
PDBsum5f5b
PubMed26805573
UniProtP09391|GLPG_ECOLI Rhomboid protease GlpG (Gene Name=glpG)

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