Structure of PDB 5f59 Chain A

Receptor sequence
>5f59A (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
SKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIR
NEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCV
AEVVTFERGHKIIISSSRRIQKGEELCYDYKFDKIPCHCGAVNCRKWM
3D structure
PDB5f59 Structural basis for activity regulation of MLL family methyltransferases.
ChainA
Resolution2.801 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y4800 I4876
Catalytic site (residue number reindexed from 1) Y44 I120
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C4851 C4899 C4901 C4906 C95 C137 C139 C144
BS02 SAH A I4780 Q4781 G4782 L4783 Y4825 R4845 Y4846 N4848 H4849 C4899 H4900 M4910 I24 Q25 G26 L27 Y69 R89 Y90 N92 H93 C137 H138 M148
External links
PDB RCSB:5f59, PDBe:5f59, PDBj:5f59
PDBsum5f59
PubMed26886794
UniProtQ8NEZ4|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)

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