Structure of PDB 5f2e Chain A

Receptor sequence
>5f2eA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TSLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHK
3D structure
PDB5f2e Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5UT A V9 G10 C12 K16 A59 G60 E62 E63 Y64 R68 D69 M72 Y96 Q99 I100 V103 V10 G11 C13 K17 A60 G61 E63 E64 Y65 R69 D70 M73 Y97 Q100 I101 V104 BindingDB: Ki=200000nM
BS02 GDP A G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 G14 G16 K17 S18 A19 F29 D31 N117 K118 D120 S146 A147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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External links
PDB RCSB:5f2e, PDBe:5f2e, PDBj:5f2e
PDBsum5f2e
PubMed26739882
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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