Structure of PDB 5f27 Chain A

Receptor sequence
>5f27A (length=187) Species: 83331 (Mycobacterium tuberculosis CDC1551) [Search protein sequence]
DRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLL
TLLDRVVNQADMALQTLAENDRENMWRTGINVFFETFGSHKAVTRAGQAA
RATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNL
MNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE
3D structure
PDB5f27 A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.
ChainA
Resolution1.684 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5TT A F110 T121 M142 W145 I146 N176 E180 L183 F83 T94 M115 W118 I119 N149 E153 L156 PDBbind-CN: -logKd/Ki=4.00,IC50>100uM
BS02 5TT A G106 F110 Y148 W207 G79 F83 Y121 W180 PDBbind-CN: -logKd/Ki=4.00,IC50>100uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5f27, PDBe:5f27, PDBj:5f27
PDBsum5f27
PubMed26806381
UniProtP9WMC1|ETHR_MYCTU HTH-type transcriptional regulator EthR (Gene Name=ethR)

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