Structure of PDB 5f20 Chain A

Receptor sequence
>5f20A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKGWKQ
EIDILRTLYHEHIIKYKGCCEDSLQLVMEYVPLGSLRDYLPRHSIGLAQL
LLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPE
GHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDS
SQSPPTKFLELIGQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCW
ETEASFRPTFENLIPILKTVHEKY
3D structure
PDB5f20 Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors.
ChainA
Resolution2.91 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) N123 A125 R127 N128 D141 P164
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5U4 A L903 G904 E905 G906 I960 Y980 V981 G984 L1030 L16 G17 E18 G19 I64 Y80 V81 G84 L130 PDBbind-CN: -logKd/Ki=7.52,IC50=30nM
BindingDB: IC50=30nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5f20, PDBe:5f20, PDBj:5f20
PDBsum5f20
PubMed26701356
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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