Structure of PDB 5f1z Chain A

Receptor sequence
>5f1zA (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
ASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKSG
WKQEIDILRTLYHEHIIKYKGCCEDKSLQLVMEYVPLGSLRDYLPRHSIG
LAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAK
AVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLT
HCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYH
LMKNCWETEASFRPTFENLIPILKTVHEKYH
3D structure
PDB5f1z Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N1023 A1025 R1027 N1028 D1041 P1064
Catalytic site (residue number reindexed from 1) N127 A129 R131 N132 D145 P168
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5U3 A L903 V911 A928 Y980 V981 P982 G984 L1030 L18 V26 A43 Y84 V85 P86 G88 L134 PDBbind-CN: -logKd/Ki=8.68,IC50=2.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5f1z, PDBe:5f1z, PDBj:5f1z
PDBsum5f1z
PubMed26701356
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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