Structure of PDB 5f0q Chain A

Receptor sequence
>5f0qA (length=187) Species: 9606 (Homo sapiens) [Search protein sequence]
KISLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLT
LEQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCLK
IILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTH
YQVACQKYFEMIHNVDDCGFSLNHPNQFFCESQRILN
3D structure
PDB5f0q Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A H300 R302 H303 R306 H31 R33 H34 R37
BS02 dna A H303 M307 K343 Y347 N348 H351 G357 K358 T360 Y362 T363 P364 F365 S366 K369 N442 H443 H34 M38 K74 Y78 N79 H82 G88 K89 T91 Y93 T94 P95 F96 S97 K100 N173 H174
BS03 SF4 A C287 C367 C384 C424 P444 C18 C98 C115 C155 P175
Gene Ontology
Biological Process
GO:0006269 DNA replication, synthesis of primer

View graph for
Biological Process
External links
PDB RCSB:5f0q, PDBe:5f0q, PDBj:5f0q
PDBsum5f0q
PubMed26975377
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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