Structure of PDB 5f0a Chain A

Receptor sequence
>5f0aA (length=811) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
GMRCNEKKKAIFSGEDTLMEDHLQLREKLSEDIEMIKASLKNNLVCSTLN
DNEILTLSNYMQFFVFKGGDLVIKQGEKGSYFFIINSGKFDVYVNDKKVK
SMGKGSSFGEAALIHNTQRSATIMAETDGTLWGVQRSTFRATLKQLSNRN
FNENRSFIDSVSVFDMLTEAQKNMITNACVIQMFKPGETIVKQGDYGDVL
FILKEGKATVFINDKEIRVLNKGSYFGERALLYDEPRSATIIAKEPTACA
SICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFRQFSAEQLNDLADTAIV
RDYPANYHILHKKVKSVKYLIVLEGKVELFLDDESIGILTRGKSFGDQYV
LNQKQKFRHTVKSLDVCKIALITESCLADCLGDNNIDASIDHNNKKSIIK
KMYIFRYLSEQQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVE
VTKNGKRLRTLGKNDYFGERALLYDEPRTASIISKATSVECWFVDKSVFL
QIIQGPMLTHLEERIKMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQ
IRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVRTFKDSNCF
YFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRD
LKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILGKGYG
CTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQ
DSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPP
LVSKGETYADF
3D structure
PDB5f0a CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND INHIBITOR
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D657 K659 N662 D675 T692
Catalytic site (residue number reindexed from 1) D650 K652 N655 D668 T685
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1FB A I540 A561 K563 F609 T611 V614 L664 I533 A554 K556 F602 T604 V607 L657
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
GO:0030553 cGMP binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5f0a, PDBe:5f0a, PDBj:5f0a
PDBsum5f0a
PubMed
UniProtA5K0N4|KGP_PLAVS cGMP-dependent protein kinase (Gene Name=PKG)

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