Structure of PDB 5f04 Chain A

Receptor sequence
>5f04A (length=191) Species: 83331 (Mycobacterium tuberculosis CDC1551) [Search protein sequence]
DRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLL
TLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRA
GQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELAT
ALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE
3D structure
PDB5f04 A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.
ChainA
Resolution1.84 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5TB A F110 F114 T121 Q125 M142 Y148 T149 N176 N179 E180 L183 F184 W207 F87 F91 T98 Q102 M119 Y125 T126 N153 N156 E157 L160 F161 W184 PDBbind-CN: -logKd/Ki=4.00,IC50>100uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5f04, PDBe:5f04, PDBj:5f04
PDBsum5f04
PubMed26806381
UniProtP9WMC1|ETHR_MYCTU HTH-type transcriptional regulator EthR (Gene Name=ethR)

[Back to BioLiP]