Structure of PDB 5ezv Chain A

Receptor sequence
>5ezvA (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]
DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV
VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK
HGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIAD
FGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL
LCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRA
TIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEV
MNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASRPHPERVPFKAKW
HLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVK
MSLQLYLVDNRSYLLDFKSIDDLGSHTMDFFEMCASLITTLA
3D structure
PDB5ezv Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.
ChainA
Resolution2.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D139 K141 E143 N144 D157 S176
Catalytic site (residue number reindexed from 1) D132 K134 E136 N137 D150 S169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
2.7.11.31: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A L22 G23 G25 V30 A43 K45 I77 M93 E94 Y95 V96 E100 E143 N144 L146 A156 L15 G16 G18 V23 A36 K38 I70 M86 E87 Y88 V89 E93 E136 N137 L139 A149
BS02 C1V A V11 L18 G19 K29 K31 I46 D88 V4 L11 G12 K22 K24 I39 D81
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ezv, PDBe:5ezv, PDBj:5ezv
PDBsum5ezv
PubMed26952388
UniProtP54646|AAPK2_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Gene Name=PRKAA2);
Q13131|AAPK1_HUMAN 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Gene Name=PRKAA1)

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