Structure of PDB 5ey9 Chain A

Receptor sequence
>5ey9A (length=610) Species: 1781 (Mycobacterium marinum) [Search protein sequence]
YHNPFIVNGKIRFPENTNLVRHVEKWARVRGDKLAYRFLDFSTERDGVER
DILWSEFSARNRAVGARLQQVTQPGDRIAILCPQNLDYLISFFGALYSGR
IAVPLFDPAEHVGRLHAVLDDCTPSTILTTTDSAEGVRKFIRSRSAKERP
RVIAVDAVPTEVASTWQQPNELTTAYLQYTVPSGVQITHLNLPTNVLQVL
NALEGQEGDRGVSWLPFFHDMGLITVLLASVLGHSFTFMTPAAFVRRPGR
WIRELARKPGETGGTFSAAPNFAFEHAAMRGVPRDDEPPLDLSNVKGILN
GSEPVSPASMRKFFKAFEPYGLRETAVKPSYGLAEATLFVSTTPMDEVPT
VIHVDRDELNKQRFVEVAADAPNAVAQVSAGKVGVDEWAVIVDTETASEL
PDGQIGEIWLHGNNLGIGYWGKEEESAQTFRNILKSRVPESHAEGAPDDG
LWVRTGDYGTYFKGHLYIAGRIKDLVIIDGRNHYPQDLEYTAQESTKALR
VGYVAAFSVPANQLPQKVFDDPHAGLSFDPEDTSEQLVIVGERAAGTHKL
EYQPIADDIRAAIAVGHGVTVRDVLLVSAGTIPRTSSGKIGRRACRTAYI
DGSLRSTVFA
3D structure
PDB5ey9 Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.20: long-chain-fatty-acid--[acyl-carrier-protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5SV A H230 D231 M232 S278 L310 S313 E314 P315 S341 Y342 G343 L344 L349 D468 I479 R482 K600 H219 D220 M221 S267 L299 S302 E303 P304 S330 Y331 G332 L333 L338 D457 I468 R471 K589 MOAD: Kd=3.87uM
PDBbind-CN: -logKd/Ki=5.41,Kd=3.87uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0016874 ligase activity
GO:0070566 adenylyltransferase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ey9, PDBe:5ey9, PDBj:5ey9
PDBsum5ey9
PubMed26900152
UniProtB2HMK0|FAA32_MYCMM Long-chain-fatty-acid--AMP ligase FadD32 (Gene Name=fadD32)

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