Structure of PDB 5ey3 Chain A

Receptor sequence
>5ey3A (length=442) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
GSMFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFF
HDMTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLML
GPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQD
VGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDA
LVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLAS
SAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARA
KLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTE
GFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRP
LAVIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE
3D structure
PDB5ey3 X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with cytidine and sulphate
ChainA
Resolution1.905 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D83 K84 H85 S86 T123 D164 R171 S186 K190 K191
Catalytic site (residue number reindexed from 1) D85 K86 H87 S88 T125 D166 R173 S188 K192 K193
Enzyme Commision number 2.4.2.4: thymidine phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTN A R115 E128 R117 E130
Gene Ontology
Molecular Function
GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
GO:0009032 thymidine phosphorylase activity
GO:0016154 pyrimidine-nucleoside phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0046104 thymidine metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ey3, PDBe:5ey3, PDBj:5ey3
PDBsum5ey3
PubMed
UniProtQ7CP66|TYPH_SALTY Thymidine phosphorylase (Gene Name=deoA)

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