Structure of PDB 5ewj Chain A

Receptor sequence
>5ewjA (length=357) Species: 8355 (Xenopus laevis) [Search protein sequence]
DPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLQATSVTHRPNAI
QMALSVCEDLISSQVYAILVSHPPLTPTPISYTAGFYRIPVIGLTTRMSI
YSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQ
KKLETLLEGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDAT
AVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESA
HISDAVAVVAQAIHELFEMENITDPPRGCVGNTNIWKTGPLFKRVLMSSK
YPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFNGSYIIQNDRKI
IWPGGET
3D structure
PDB5ewj A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
ChainA
Resolution2.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QEL A Y109 S132 L135 Y82 S105 L108 PDBbind-CN: -logKd/Ki=6.89,IC50=130nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5ewj, PDBe:5ewj, PDBj:5ewj
PDBsum5ewj
PubMed26912815
UniProtA0A1L8F5J9|NMDZ1_XENLA Glutamate receptor ionotropic, NMDA 1 (Gene Name=grin1)

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