Structure of PDB 5ev3 Chain A

Receptor sequence

>5ev3A (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]

TRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQD
KNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSV
YVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDS
ATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAK

3D structure

PDB

5ev3 An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.

Chain

Resolution

1.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R146 Q147 R150 Y152 K195 F197 F199 K225 R227 R228 P229 H230 D231 T252 V254 K260 F262 G264 G265 N289 Y302 F304 K328 K329 A335 G338 A339 K340	R2 Q3 R6 Y8 K51 F53 F55 K81 R83 R84 P85 H86 D87 T108 V110 K116 F118 G120 G121 N145 Y158 F160 K184 K185 A191 G194 A195 K196

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

	Biological Process
GO:0006397	mRNA processing

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5ev3, PDBe:5ev3, PDBj:5ev3
PDBsum	5ev3
PubMed	26952537
UniProt	P26368\|U2AF2_HUMAN Splicing factor U2AF 65 kDa subunit (Gene Name=U2AF2)

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