Structure of PDB 5eu8 Chain A

Receptor sequence
>5eu8A (length=300) Species: 11135 (Feline infectious peritonitis virus) [Search protein sequence]
SSGLRKMAQPSGVVEPCIVRVAYGNNVLNGLWLGDEVICPRHVIASDTSR
VINYENELSSVRLHNFSIAKNNAFLGVVSAKYKGVNLVLKVNQVNPNTPE
HKFKSVRPGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGY
VLENGTLYFVYMHHLELGNGSHVGSNLEGEMYGGYEDQPSMQLEGTNVMS
SDNVVAFLYAALINGERWFVTNTSMTLESYNAWAKTNSFTEIVSTDAFNM
LAAKTGYSVEKLLECIVRLNKGFGGRTILSYGSLCDEFTPTEVIRQMYGV
3D structure
PDB5eu8 Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors
ChainA
Resolution2.447 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H42 G143 C145
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H41 C144 H163 L164 E165 Q187 P188 S189 M190 H42 C145 H164 L165 E166 Q188 P189 S190 M191
BS02 ZN A N25 V26 H41 H163 D186 N26 V27 H42 H164 D187
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5eu8, PDBe:5eu8, PDBj:5eu8
PDBsum5eu8
PubMed26656689
UniProtQ98VG9|R1AB_FIPV Replicase polyprotein 1ab (Gene Name=rep)

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