Structure of PDB 5eth Chain A

Receptor sequence
>5ethA (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
EIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWE
RCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRA
YNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIA
LYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPP
KGKLRSLCSQHVERLQIF
3D structure
PDB5eth Discovery of biaryls as ROR gamma inverse agonists by using structure-based design.
ChainA
Resolution2.803 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5RT A C320 H323 L324 A327 M365 V376 F378 F388 I400 F401 V480 C52 H55 L56 A59 M97 V108 F110 F120 I132 F133 V212 PDBbind-CN: -logKd/Ki=7.25,IC50=0.056uM
BindingDB: IC50=56nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5eth, PDBe:5eth, PDBj:5eth
PDBsum5eth
PubMed27080181
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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