Structure of PDB 5esk Chain A

Receptor sequence

>5eskA (length=527) Species: 307796 (Saccharomyces cerevisiae YJM789)

VGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPP
LVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPK
GHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGA
LTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFT
ASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHA
QKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANL
LIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTY
DLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVL
VSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVS
SPYLPFSGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFT
SMVTLPTGPAKIIWEKRNPEQKIGGRH

3D structure

• PDB: 5esk Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase.
• Chain: A
• Resolution: 2.24 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1YN	A	A69 Y72 G73 Y126 F134 Y140 F236 P238 G310 V311 G314 F384 T507 M509	A62 Y65 G66 Y119 F127 Y133 F229 P231 G303 V304 G307 F377 T500 M502
BS02	HEM	A	Y126 Y140 L147 K151 V311 G315 T318 P379 L383 R385 P462 F463 S464 H468 C470 G472	Y119 Y133 L140 K144 V304 G308 T311 P372 L376 R378 P455 F456 S457 H461 C463 G465

Gene Ontology

Molecular Function

• GO:0004497 monooxygenase activity
• GO:0005506 iron ion binding
• GO:0008168 methyltransferase activity
• GO:0016491 oxidoreductase activity
• GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006696 ergosterol biosynthetic process
• GO:0016126 sterol biosynthetic process
• GO:0032259 methylation

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5esk, PDBe:5esk, PDBj:5esk
• PDBsum: 5esk
• PubMed: 29263059
• UniProt: A6ZSR0