Structure of PDB 5erd Chain A

Receptor sequence

>5erdA (length=554) Species: 9606 (Homo sapiens) [Search protein sequence]

AWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPF
GIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKV
LDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYR
IVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVT
DKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDAD
EIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLD
FSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSE
SMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKL
AKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTL
IEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQ
ESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGC
REAH

3D structure

PDB

5erd Structural basis of adhesive binding by desmocollins and desmogleins.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MAN	A	R429 T431	R429 T431
BS02	MAN	A	S342 T433 T435	S342 T433 T435
BS03	CA	A	E11 R70 E71 D102 I103 D105 D138	E11 R70 E71 D102 I103 D105 D138
BS04	CA	A	E11 D69 E71 D105	E11 D69 E71 D105
BS05	CA	A	N104 N106 D136 D138 N144 D194	N104 N106 D136 D138 N144 D194
BS06	CA	A	E121 E181 D215 V216 D218 D250	E121 E181 D215 V216 D218 D250
BS07	CA	A	E121 D179 E181 D218	E121 D179 E181 D218
BS08	CA	A	N217 N219 D248 D250 N256 N307	N217 N219 D248 D250 N256 N307
BS09	CA	A	E350 E407 D442 I443 D445 D472	E350 E407 D442 I443 D445 D472
BS10	CA	A	N444 N446 D470 D472 N476 D525	N444 N446 D470 D472 N476 D525
BS11	CA	A	E234 E294 N332 V333 E335 D370	E234 E294 N332 V333 E335 D370
BS12	CA	A	E234 D292 E294 E335 E369	E234 D292 E294 E335 E369
BS13	CA	A	E350 D405 E407 D445	E350 D405 E407 D445

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5erd, PDBe:5erd, PDBj:5erd
PDBsum	5erd
PubMed	27298358
UniProt	Q14126\|DSG2_HUMAN Desmoglein-2 (Gene Name=DSG2)

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