Structure of PDB 5eqx Chain A

Receptor sequence

>5eqxA (length=439) Species: 9606 (Homo sapiens)

EWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGI
FVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILD
INDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIV
SQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLST
QCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTD
NWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAV
KNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSK
KLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKN
MNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDF

3D structure

• PDB: 5eqx Structural basis of adhesive binding by desmocollins and desmogleins.
• Chain: A
• Resolution: 3.05 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E11 E69 D100 I101 D103 D136	E11 E69 D100 I101 D103 D136
BS02	CA	A	N212 N214 D243 D245 N251 N302	N212 N214 D243 D245 N251 N302
BS03	CA	A	E11 D67 E69 D103	E11 D67 E69 D103
BS04	CA	A	N102 N104 D134 D136 N142 D192	N102 N104 D134 D136 N142 D192
BS05	CA	A	E119 N120 D177 E179 D213	E119 N120 D177 E179 D213
BS06	CA	A	E119 E179 D210 V211 D213 D245	E119 E179 D210 V211 D213 D245
BS07	CA	A	E229 E289 N327 V328 E330 D366	E229 E289 N327 V328 E330 D366
BS08	CA	A	E229 D287 E289 E330	E229 D287 E289 E330
BS09	MAN	A	E416 T429	E416 T429
BS10	MAN	A	E416 T431	E416 T431
BS11	MAN	A	G425 T427	G425 T427

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5eqx, PDBe:5eqx, PDBj:5eqx
• PDBsum: 5eqx
• PubMed: 27298358
• UniProt: P32926|DSG3_HUMAN Desmoglein-3 (Gene Name=DSG3)