Structure of PDB 5eok Chain A

Receptor sequence
>5eokA (length=589) Species: 9606 (Homo sapiens) [Search protein sequence]
CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSED
PTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLD
MKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKH
TQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVM
APDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRI
KKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQK
LCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGY
TLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGS
IIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIH
DQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGW
GYDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYKGDSGGPLSC
KHNEVWHLVGITSWGEGCERPGVYTNVVEYVDWILEKTQ
3D structure
PDB5eok A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H413 D462 K554 G555 D556 S557 G558
Catalytic site (residue number reindexed from 1) H412 D461 K541 G542 D543 S544 G545
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K103 N106 Y107 S109 A134 P139 H143 I146 K102 N105 Y106 S108 A133 P138 H142 I145
BS02 FUC A R121 D125 R120 D124
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008236 serine-type peptidase activity
GO:0070009 serine-type aminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0030193 regulation of blood coagulation
GO:0031639 plasminogen activation
GO:0051919 positive regulation of fibrinolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5eok, PDBe:5eok, PDBj:5eok
PDBsum5eok
PubMed27006387
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

[Back to BioLiP]