Structure of PDB 5eob Chain A

Receptor sequence
>5eobA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
LSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKK
IHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPL
VVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRD
LAARNCMLDEKFTVKVADFGLARDMYDKEYYSVTGAKLPVKWMALESLQT
QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY
CPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFI
3D structure
PDB5eob Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222 A1243
Catalytic site (residue number reindexed from 1) D150 A152 R154 N155 D168 A186
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5QQ A A1108 Y1159 M1160 D1164 R1208 M1211 A1221 D1222 Y1230 A54 Y105 M106 D110 R154 M157 A167 D168 Y176 MOAD: ic50=0.24nM
PDBbind-CN: -logKd/Ki=9.62,IC50=0.24nM
BindingDB: IC50=0.850000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5eob, PDBe:5eob, PDBj:5eob
PDBsum5eob
PubMed27061987
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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