Structure of PDB 5eni Chain A

Receptor sequence
>5eniA (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMD
FATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSA
FFEEHISSVLSDYKSALRFHKRN
3D structure
PDB5eni A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
ChainA
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5QA A P1340 V1345 Y1350 Y1353 Y1395 P28 V33 Y38 Y41 Y83 PDBbind-CN: -logKd/Ki=2.30,IC50>5mM
External links
PDB RCSB:5eni, PDBe:5eni, PDBj:5eni
PDBsum5eni
PubMed29910922
UniProtQ8WWQ0|PHIP_HUMAN PH-interacting protein (Gene Name=PHIP)

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