Structure of PDB 5enh Chain A

Receptor sequence
>5enhA (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMD
FATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSA
FFEEHISSVLSDYKSALRFHKRN
3D structure
PDB5enh A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5QB A P1340 F1341 V1345 Y1350 Y1395 P28 F29 V33 Y38 Y83 PDBbind-CN: -logKd/Ki=3.72,IC50=0.19mM
External links
PDB RCSB:5enh, PDBe:5enh, PDBj:5enh
PDBsum5enh
PubMed29910922
UniProtQ8WWQ0|PHIP_HUMAN PH-interacting protein (Gene Name=PHIP)

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