Structure of PDB 5ene Chain A

Receptor sequence
>5eneA (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMD
FATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSA
FFEEHISSVLSDYKSALRFHKRN
3D structure
PDB5ene A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
ChainA
Resolution1.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5Q8 A F1341 V1345 Y1350 T1396 F29 V33 Y38 T84 PDBbind-CN: -logKd/Ki=3.23,IC50=0.59mM
External links
PDB RCSB:5ene, PDBe:5ene, PDBj:5ene
PDBsum5ene
PubMed29910922
UniProtQ8WWQ0|PHIP_HUMAN PH-interacting protein (Gene Name=PHIP)

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