Structure of PDB 5enb Chain A

Receptor sequence
>5enbA (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
SMSYDIQAWKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMD
FATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSA
FFEEHISSVLSDYKSALRFHKRN
3D structure
PDB5enb A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.
ChainA
Resolution1.73 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5Q5 A Y1350 Y1353 N1391 S1392 Y1395 Y38 Y41 N79 S80 Y83 PDBbind-CN: -logKd/Ki=3.11,IC50=0.78mM
External links
PDB RCSB:5enb, PDBe:5enb, PDBj:5enb
PDBsum5enb
PubMed29910922
UniProtQ8WWQ0|PHIP_HUMAN PH-interacting protein (Gene Name=PHIP)

[Back to BioLiP]