Structure of PDB 5en4 Chain A

Receptor sequence
>5en4A (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
GTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQEL
PGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETS
AQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVP
YVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPR
ATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGY
G
3D structure
PDB5en4 First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.
ChainA
Resolution1.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G20 S141 A151 Y154 K158
Catalytic site (residue number reindexed from 1) G17 S138 A148 Y151 K155
Enzyme Commision number 1.1.1.62: 17beta-estradiol 17-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G16 R19 G20 I21 D40 K41 D62 V63 N89 L113 S141 Y154 K158 P184 G185 I187 T189 L191 G13 R16 G17 I18 D37 K38 D59 V60 N86 L110 S138 Y151 K155 P181 G182 I184 T186 L188
BS02 5Q6 A H93 S141 Q148 A149 Q150 Y154 N186 W192 L195 H90 S138 Q145 A146 Q147 Y151 N183 W189 L192 MOAD: Ki=64nM
BindingDB: Ki=64nM
Gene Ontology
Molecular Function
GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
Biological Process
GO:0006706 steroid catabolic process
GO:0008202 steroid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5en4, PDBe:5en4, PDBj:5en4
PDBsum5en4
PubMed27933965
UniProtQ9BPX1|DHB14_HUMAN 17-beta-hydroxysteroid dehydrogenase 14 (Gene Name=HSD17B14)

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