Structure of PDB 5eky Chain A

Receptor sequence
>5ekyA (length=248) Species: 562 (Escherichia coli) [Search protein sequence]
DLKASSLRALKLMDLTTLNDDDTDEKVIALCHQAKTPVGNTAAICIYPRF
IPIARETLKEQGTPEIRIATVTNFPHGNDDIDIALAETRAAIAWGADEVD
VVFPYRALMAGNEQVGFDLVKACKEACAAANVLLKVIIETGELKDEALIR
KASEISIKAGADFIKTSTGKVAVNATPESARIMMEVIRDMGVEKTVGFKP
AGGVRTAEDAQKYLAIADELFGADWADARHYRFGASSLLASLLKALGH
3D structure
PDB5eky Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies.
ChainA
Resolution1.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D102 K167 K201
Catalytic site (residue number reindexed from 1) D100 K165 K199
Enzyme Commision number 4.1.2.4: deoxyribose-phosphate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BU2 A K167 T170 G171 A203 H250 K165 T168 G169 A201 H248
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004139 deoxyribose-phosphate aldolase activity
GO:0016829 lyase activity
Biological Process
GO:0006018 2-deoxyribose 1-phosphate catabolic process
GO:0006974 DNA damage response
GO:0009264 deoxyribonucleotide catabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0016052 carbohydrate catabolic process
GO:0046386 deoxyribose phosphate catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5eky, PDBe:5eky, PDBj:5eky
PDBsum5eky
PubMed30155096
UniProtP0A6L0|DEOC_ECOLI Deoxyribose-phosphate aldolase (Gene Name=deoC)

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