Structure of PDB 5ejv Chain A

Receptor sequence
>5ejvA (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
PYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKS
MWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVL
VRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHF
SEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSI
LAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB5ejv Discovery of biaryls as ROR gamma inverse agonists by using structure-based design.
ChainA
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 Q346 K354 P500 E504 K74 Q84 K92 P238 E242
BS02 444 A W317 C320 A321 L324 M365 I397 I400 H479 W55 C58 A59 L62 M103 I135 I138 H217 PDBbind-CN: -logKd/Ki=6.69,IC50=0.204uM
BindingDB: IC50=60nM,EC50=54nM,Ki=51nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:5ejv, PDBe:5ejv, PDBj:5ejv
PDBsum5ejv
PubMed27080181
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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