Structure of PDB 5eiw Chain A

Receptor sequence
>5eiwA (length=256) Species: 11069 (dengue virus type 3) [Search protein sequence]
ETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVS
RGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKG
GPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTV
EESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVR
NPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVD
LGAGTR
3D structure
PDB5eiw Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
ChainA
Resolution1.611 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A S56 G58 G81 G86 W87 T104 K105 H110 K130 D131 V132 F133 D146 S50 G52 G75 G80 W81 T98 K99 H104 K124 D125 V126 F127 D140
BS02 X0V A G107 P108 E112 G101 P102 E106 PDBbind-CN: -logKd/Ki=2.05,IC50=9mM
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5eiw, PDBe:5eiw, PDBj:5eiw
PDBsum5eiw
PubMed27750202
UniProtQ6YMS4|POLG_DEN3S Genome polyprotein (Gene Name=pol)

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