Structure of PDB 5eiu Chain A

Receptor sequence
>5eiuA (length=134) Species: 9544,262724 [Search protein sequence]
DHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKL
QTALEMLRQKQQEAETERNQVAKRVPKAPPEEKEALIARGKALGEQTQYM
RELISELEHRLQGSMMDLLQGVDGIIKRIENMTL
3D structure
PDB5eiu Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5 alpha.
ChainA
Resolution1.908 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K221
Catalytic site (residue number reindexed from 1) K127
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
6.1.1.11: serine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C108 D111 H125 H128 C14 D17 H31 H34
BS02 ZN A C97 H100 C116 C119 C3 H6 C22 C25
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5eiu, PDBe:5eiu, PDBj:5eiu
PDBsum5eiu
PubMed27253059
UniProtP34945|SYS_THET2 Serine--tRNA ligase (Gene Name=serS);
Q0PF16|TRIM5_MACMU Tripartite motif-containing protein 5 (Gene Name=TRIM5)

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