Structure of PDB 5ei4 Chain A

Receptor sequence
>5ei4A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5ei4 Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.
ChainA
Resolution1.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5NV A W81 P82 Q85 V87 D88 L92 N140 W40 P41 Q44 V46 D47 L51 N99 MOAD: ic50=26.4uM
PDBbind-CN: -logKd/Ki=4.58,IC50=26.4uM
External links
PDB RCSB:5ei4, PDBe:5ei4, PDBj:5ei4
PDBsum5ei4
PubMed26735842
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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