Structure of PDB 5ehi Chain A

Receptor sequence
>5ehiA (length=256) Species: 408870 (Dengue virus 3 Philippines/H87/1956) [Search protein sequence]
ETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVS
RGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKG
GPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTV
EESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVR
NPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVD
LGAGTR
3D structure
PDB5ehi Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
ChainA
Resolution1.303 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A S56 G58 G81 G86 W87 K105 H110 K130 D131 V132 F133 D146 S50 G52 G75 G80 W81 K99 H104 K124 D125 V126 F127 D140
BS02 5O3 A W64 R68 M70 M233 L237 W58 R62 M64 M227 L231 PDBbind-CN: -logKd/Ki=3.34,IC50=452uM
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ehi, PDBe:5ehi, PDBj:5ehi
PDBsum5ehi
PubMed27750202
UniProtP27915|POLG_DEN3P Genome polyprotein

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