Structure of PDB 5egm Chain A

Receptor sequence
>5egmA (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGASALVLQYLRVPL
VDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
3D structure
PDB5egm Development of a novel tricyclic class of potent and selective FIXa inhibitors.
ChainA
Resolution1.841 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D89 Q182 G183 D184 S185 G186
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5NY A H57 Y99 H147 F174 C191 Q192 S195 W215 G216 E217 H41 Y86 H135 F162 C181 Q182 S185 W205 G206 E207 MOAD: Ki=2.4nM
PDBbind-CN: -logKd/Ki=8.62,Ki=2.4nM
BindingDB: IC50=2.38nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5egm, PDBe:5egm, PDBj:5egm
PDBsum5egm
PubMed26318999
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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