Structure of PDB 5efq Chain A

Receptor sequence
>5efqA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEG
FPITAIREIKILRQLTHQSIINMKEIVTDKEGAFYLVFEYMDHDLMGLLE
SGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKL
ADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI
LGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPK
KQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEP
SKMPPPDLPLWQDCHELWSKKR
3D structure
PDB5efq Structural and Functional Analysis of the Cdk13/Cyclin K Complex.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D837 K839 S841 N842 D855 S867 T876
Catalytic site (residue number reindexed from 1) D134 K136 S138 N139 D152 S164 T173
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T715 A732 K734 M794 D797 S841 L844 D855 H1018 T21 A38 K40 M91 D94 S138 L141 D152 H315
BS02 AF3 A D837 K839 N842 D855 D134 K136 N139 D152
BS03 MG A N842 D855 N139 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5efq, PDBe:5efq, PDBj:5efq
PDBsum5efq
PubMed26748711
UniProtQ14004|CDK13_HUMAN Cyclin-dependent kinase 13 (Gene Name=CDK13)

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