Structure of PDB 5efh Chain A

Receptor sequence
>5efhA (length=356) Species: 7955 (Danio rerio) [Search protein sequence]
ITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPAR
LATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCA
LLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALT
ARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAF
FPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIARE
FAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILE
GGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAP
FWSSLR
3D structure
PDB5efh Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
ChainA
Resolution2.162 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D612 H614 D705 D170 H172 D263
BS02 FKS A P571 H573 H574 G582 F583 D612 H614 F643 E742 G743 Y745 P129 H131 H132 G140 F141 D170 H172 F201 E300 G301 Y303 MOAD: Ki=0.8uM
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