Structure of PDB 5ef7 Chain A

Receptor sequence
>5ef7A (length=358) Species: 7955 (Danio rerio) [Search protein sequence]
SPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIP
ARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYT
CALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAA
LTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDG
AFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIA
REFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLII
LEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAH
APFWSSLR
3D structure
PDB5ef7 Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D612 H614 D705 D172 H174 D265
BS02 5OJ A S531 H574 G582 F583 H614 F643 D705 L712 Y745 S91 H134 G142 F143 H174 F203 D265 L272 Y305 MOAD: Ki=1nM
PDBbind-CN: -logKd/Ki=9.00,Ki=1nM
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