Structure of PDB 5edu Chain A

Receptor sequence
>5eduA (length=720) Species: 9606,83333 [Search protein sequence]
KLVIWINGDKGYNGLAEVGKKFEKGIKVTVEHPDKLEEKFPQVAATGDGP
DIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYP
IAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFT
WPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNAD
TDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKP
FVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSY
EEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTV
DAALAAAQTNAAASRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLE
ELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSN
FDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQD
AACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPS
VLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADY
LAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHL
LMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSG
ALASITETIQVHRRYWRSLR
3D structure
PDB5edu Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
ChainA
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A D173 R174 E261 P262 Y263 W448 D58 R59 E146 P147 Y148 W333
BS02 GLC A K123 E219 Y263 W338 K10 E104 Y148 W223
BS03 ZN A D649 H651 D742 D534 H536 D627
BS04 TSN A P501 H610 H611 F620 H651 F680 Y782 P386 H495 H496 F505 H536 F565 Y667
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5edu, PDBe:5edu, PDBj:5edu
PDBsum5edu
PubMed27454933
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q9UBN7|HDAC6_HUMAN Histone deacetylase 6 (Gene Name=HDAC6)

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