Structure of PDB 5ed4 Chain A

Receptor sequence
>5ed4A (length=222) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRARETRPDA
VILDVMMPGMDGFGVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDD
YVTKPFSLEEVVARLRVILRRAGVRLTFADIELDEETHEVWKAGQPVSLS
PTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKI
DTGEKRLLHTLRGVGYVLREPR
3D structure
PDB5ed4 Structural basis of DNA sequence recognition by the response regulator PhoP in Mycobacterium tuberculosis.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.1: alkaline phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S175 T177 W203 R204 N212 Y217 Y220 S150 T152 W178 R179 N187 Y192 Y195
BS02 dna A K195 E215 S219 R222 R223 T235 R237 G238 Y241 K170 E190 S194 R197 R198 T210 R212 G213 Y216
BS03 CA A D28 D71 M73 D11 D54 M56
Gene Ontology
Molecular Function
GO:0000156 phosphorelay response regulator activity
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006355 regulation of DNA-templated transcription
GO:0006979 response to oxidative stress
GO:0009247 glycolipid biosynthetic process
GO:0010628 positive regulation of gene expression
GO:0044315 protein secretion by the type VII secretion system
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0046889 positive regulation of lipid biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ed4, PDBe:5ed4, PDBj:5ed4
PDBsum5ed4
PubMed27079268
UniProtP71814

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