Structure of PDB 5ebt Chain A

Receptor sequence
>5ebtA (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
MTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVV
NKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRV
TLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEY
LITYQIMKPE
3D structure
PDB5ebt Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BU3 A A1202 Y1203 F1208 A98 Y99 F104
BS02 5N8 A H1184 G1185 F1188 F1197 D1198 H1201 A1202 F1208 I1212 Y1213 S1221 Y1224 I1228 H80 G81 F84 F93 D94 H97 A98 F104 I108 Y109 S117 Y120 I124
BS03 ZN A C1234 H1237 C1242 C1245 C130 H133 C138 C141
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5ebt, PDBe:5ebt, PDBj:5ebt
PDBsum5ebt
PubMed26546219
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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