Structure of PDB 5e9q Chain A

Receptor sequence
>5e9qA (length=255) Species: 11069 (dengue virus type 3) [Search protein sequence]
ETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVS
RGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKTEVRGYTKGG
PGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTVE
ESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRN
PLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVDL
GAGTR
3D structure
PDB5e9q Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A S56 G58 G81 G86 W87 T104 K105 H110 E111 K130 D131 V132 F133 D146 S50 G52 G75 G80 W81 T97 K98 H103 E104 K123 D124 V125 F126 D139
BS02 5KY A G107 P108 G109 H110 E111 E112 G100 P101 G102 H103 E104 E105
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5e9q, PDBe:5e9q, PDBj:5e9q
PDBsum5e9q
PubMed27750202
UniProtP27915|POLG_DEN3P Genome polyprotein

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