Structure of PDB 5e9c Chain A

Receptor sequence
>5e9cA (length=385) Species: 9606 (Homo sapiens) [Search protein sequence]
KFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLL
DYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTF
KNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATRE
DFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDT
FAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSL
LFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLH
NVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTL
PPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
3D structure
PDB5e9c Structural characterization of human heparanase reveals insights into substrate recognition.
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.166: heparanase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5KV A E225 G269 Q270 H296 Y298 Y348 E67 G111 Q112 H138 Y140 Y190
BS02 IDR A Y298 E343 Y348 G349 G350 Y391 Y140 E185 Y190 G191 G192 Y233
BS03 SGN A K159 F160 V384 A388 G389 Y391 K1 F2 V226 A230 G231 Y233
BS04 SO4 A D399 P400 K501 M502 D241 P242 K343 M344
Gene Ontology
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:5e9c, PDBe:5e9c, PDBj:5e9c
PDBsum5e9c
PubMed26575439
UniProtQ9Y251|HPSE_HUMAN Heparanase (Gene Name=HPSE)

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