Structure of PDB 5e8w Chain A

Receptor sequence
>5e8wA (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
MTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEI
YQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
VEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCC
IADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKR
ADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQ
KLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ
EGI
3D structure
PDB5e8w Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity.
ChainA
Resolution1.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D333 K335 N338 D351 T375
Catalytic site (residue number reindexed from 1) D135 K137 N140 D153 T177
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A I211 K213 V219 A230 L260 Y282 H283 G286 K337 L340 D351 I13 K15 V21 A32 L62 Y84 H85 G88 K139 L142 D153 PDBbind-CN: -logKd/Ki=4.39,IC50=41uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5e8w, PDBe:5e8w, PDBj:5e8w
PDBsum5e8w
PubMed27139629
UniProtP36897|TGFR1_HUMAN TGF-beta receptor type-1 (Gene Name=TGFBR1)

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