Structure of PDB 5e7v Chain A

Receptor sequence
>5e7vA (length=239) Species: 7955 (Danio rerio) [Search protein sequence]
HMLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVRRLSMLPHLADLVS
YSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMS
WSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMA
ICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKL
ADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEV
3D structure
PDB5e7v Carborane-based design of a potent vitamin D receptor agonist.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I270 K274 R280 A284 I288 K292 E446 I57 K61 R67 A71 I75 K79 E233
BS02 M7E A Y175 L255 L258 A259 V262 S265 R302 S303 S306 W314 C316 H333 H423 Y427 L430 L440 Y22 L42 L45 A46 V49 S52 R89 S90 S93 W101 C103 H120 H210 Y214 L217 L227 MOAD: ic50=2.9nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:5e7v, PDBe:5e7v, PDBj:5e7v
PDBsum5e7v
PubMed28808527
UniProtQ9PTN2|VDRA_DANRE Vitamin D3 receptor A (Gene Name=vdra)

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